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Ageing: Much ado about ageing

Questions about a laboratory assay are making Sirtris, a high-profile biotechnology company, the talking point of the ageing field. Heidi Ledford investigates.

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References

  1. Kaeberlein, M., McVey, M. & Guarente, L. Genes Dev. 13, 2570-2580 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Pacholec, M. et al. J. Biol. Chem. 285, 8340-8351 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Howitz, K. T. et al. Nature 425, 191-196 (2003).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Kaeberlein, M. et al. J. Biol. Chem. 280, 17038-17045 (2005).

    Article  CAS  PubMed  Google Scholar 

  5. Borra, M. T., Smith, B. C. & Denu, J. M. J. Biol. Chem. 280, 17187-17195 (2005).

    Article  CAS  PubMed  Google Scholar 

  6. Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D. & Partridge, L. Mech. Age. Develop. 128, 546-552 (2007).

    Article  CAS  Google Scholar 

  7. Baur, J. A. et al. Nature 444, 337-342 (2006).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  8. Milne, J. C. et al. Nature 450, 712-716 (2007).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  9. Liu, Y. et al. Nature 456, 269-273 (2008).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  10. Feige, J. N. et al. Cell Metab. 8, 347-358 (2008).

    Article  CAS  PubMed  Google Scholar 

  11. Yamazaki, Y. et al. Am. J. Physiol. Endocrinol. Metab. 297, E1179-E1186 (2009).

    Article  CAS  PubMed  Google Scholar 

Download references

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Additional information

See Editorial, page 465 , and Ageing Insight, page 503 .

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Web Focus: Determining Lifespan

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Sirtris Pharmaceuticals

National Institute on Ageing

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Ledford, H. Ageing: Much ado about ageing. Nature 464, 480–481 (2010). https://doi.org/10.1038/464480a

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