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Cell biology

Actin filaments up against a wall

The front of motile cells is thought to be pushed out by branched filaments of actin protein abutting the cell membrane. New work challenges this textbook view, showing that actin branches grow away from, or obliquely to, a surface.

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Figure 1: Actin-network assembly gets a fresh look.

References

  1. Pollard, T. D. & Borisy, G. G. Cell 112, 453–465 (2003).

    Article  CAS  Google Scholar 

  2. Plastino, J. & Sykes, C. Curr. Opin. Cell Biol. 17, 62–66 (2005).

    Article  CAS  Google Scholar 

  3. Achard, V. et al. Curr. Biol. 20, 423–428 (2010).

    Article  CAS  Google Scholar 

  4. Machesky, L. M. et al. Proc. Natl Acad. Sci. USA 96, 3739–3744 (1999).

    Article  CAS  ADS  Google Scholar 

  5. Amann, K. J. & Pollard, T. D. Proc. Natl Acad. Sci. USA 98, 15009–15013 (2001).

    Article  CAS  ADS  Google Scholar 

  6. Wang, Y. L. J. Cell Biol. 101, 597–602 (1985).

    Article  CAS  Google Scholar 

  7. Cameron, L. A. et al. Curr. Biol. 11, 130–135 (2001).

    Article  CAS  Google Scholar 

  8. Paluch, E., van der Gucht, J., Joanny, J.-F. & Sykes, C. Biophys. J. 91, 3113–3122 (2006).

    Article  CAS  ADS  Google Scholar 

  9. Svitkina, T. M., Verkhovsky, A. B., McQuade, K. M. & Borisy, G. G. J. Cell Biol. 139, 397–415 (1997).

    Article  CAS  Google Scholar 

  10. Koestler, S. A. et al. Nature Cell Biol. 10, 306–313 (2008).

    Article  CAS  Google Scholar 

  11. Gupton, S. L., Eisenmann, K., Alberts, A. S. & Waterman-Storer, C. M. J. Cell Sci. 120, 3475–3487 (2007).

    Article  CAS  Google Scholar 

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Sykes, C., Plastino, J. Actin filaments up against a wall. Nature 464, 365–366 (2010). https://doi.org/10.1038/464365a

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