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Supramolecular chemistry

Sticking to sugars

If evolution has had trouble making effective carbohydrate receptors, what hope do humans have of creating synthetic versions? A method for preparing libraries of such receptors boosts the chances of success.

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Figure 1: Synthetic carbohydrate receptors.


  1. Pal, A., Bérubé, M. & Hall, D. G. Angew. Chem. Int. Edn 49, 1492–1495 (2010). | Article |

    Article  CAS  Google Scholar 

  2. Toone, E. J. Curr. Opin. Struct. Biol. 4, 719–728 (1994).

    Article  CAS  Google Scholar 

  3. Laine, R. A. Glycobiology 4, 759–767 (1994).

    Article  CAS  Google Scholar 

  4. Gabius, H.-J. (ed.) The Sugar Code: Fundamentals of Glycosciences (Wiley, 2009).

    Google Scholar 

  5. Davis, A. P. & Wareham, R. S. Angew. Chem. Int. Edn 38, 2978–2996 (1999).

    Article  CAS  Google Scholar 

  6. Kubik, S. Angew. Chem. Int. Edn 48, 1722–1725 (2009).

    Article  CAS  Google Scholar 

  7. Ferrand, Y., Crump, M. P. & Davis, A. P. Science 318, 619–622 (2007).

    Article  ADS  CAS  Google Scholar 

  8. James, T. D., Sandanayake, K. R. A. S. & Shinkai, S. Angew. Chem. Int. Edn Engl. 35, 1910–1922 (1996).

    Article  Google Scholar 

  9. James, T. D., Phillips, M. D. & Shinkai, S. Boronic Acids in Saccharide Recognition (R. Soc. Chem., 2006).

    Google Scholar 

  10. Yu, L.-G. Glycoconjugate J. 24, 411–420 (2007).

    Article  CAS  Google Scholar 

  11. Bérubé, M., Dowlut, M. & Hall, D. G. J. Org. Chem. 73, 6471–6479 (2008).

    Article  Google Scholar 

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Davis, A. Sticking to sugars. Nature 464, 169–170 (2010).

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