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Clinical immunology

Culprits with evolutionary ties

The cellular organelles we know as mitochondria are thought to have originated as symbiotic bacteria. Indeed, the two use common mechanisms to trigger innate immune responses to injury and infection, respectively.

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Figure 1: PAMPs, DAMPs and the inflammatory response.

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Calfee, C., Matthay, M. Culprits with evolutionary ties. Nature 464, 41–42 (2010). https://doi.org/10.1038/464041a

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