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Neuroscience

Lack of inhibition leads to abuse

Chronic drug use can lead to addiction, which is initiated by specific brain circuits. The mystery of how one class of drugs, the benzodiazepines, affects activity in this circuitry has finally been solved.

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Figure 1: Proposed mechanism of addiction of benzodiazepine drugs.

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Riegel, A., Kalivas, P. Lack of inhibition leads to abuse. Nature 463, 743–744 (2010). https://doi.org/10.1038/463743a

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