Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Stability in times of stress

Damaged lysosomes, the principal degradative organelles, can kill a cell. A stress-induced protein controls lysosome stability, providing a potential target to treat lysosome-related diseases and cancer.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: A protein–lipid interaction stabilizes lysosome membranes.


  1. Kirkegaard, T. et al. Nature 463, 549–553 (2010).

    Article  ADS  CAS  Google Scholar 

  2. Tissières, A., Mitchell, H. K. & Tracy, U. M. J. Mol. Biol. 84, 389–398 (1974).

    Article  Google Scholar 

  3. Ellis, J. Nature 328, 378–379 (1987).

    Article  ADS  CAS  Google Scholar 

  4. Horváth, I., Multhoff, G., Sonnleitner, A. & Vígh, L. Biochim. Biophys. Acta 1778, 1653–1664 (2008).

    Article  Google Scholar 

  5. Henderson, B. Cell Biochem. Funct. 28, 1–14 (2009).

    Article  Google Scholar 

  6. Nylandsted, J. et al. J. Exp. Med. 200, 425–435 (2004).

    Article  CAS  Google Scholar 

  7. Heinrich, M. et al. Adv. Exp. Med. Biol. 477, 305–315 (2000).

    Article  CAS  Google Scholar 

  8. Vigh, L., Horváth, I., Maresca, B. & Harwood, J. L. Trends Biochem. Sci. 32, 357–363 (2007).

    Article  CAS  Google Scholar 

  9. Gehrmann, M. et al. PloS ONE 3, e1925 (2008).

    Article  ADS  Google Scholar 

  10. Escribá, P. V. Trends Mol. Med. 12, 34–43 (2006).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Horváth, I., Vígh, L. Stability in times of stress. Nature 463, 436–438 (2010).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing