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Five hard truths for synthetic biology

Can engineering approaches tame the complexity of living systems? Roberta Kwok explores five challenges for the field and how they might be resolved.

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  1. Purnick, P. E. M. & Weiss, R. Nature Rev. Mol. Cell Biol. 10, 410-422 (2009).

    Article  CAS  Google Scholar 

  2. Kelly, J. R. et al. J. Biol. Engineer. 3, 4 (2009).

    Article  Google Scholar 

  3. Gardner, T. S., Cantor, C. R. & Collins, J. J. Nature 403, 339-342 (2000).

    Article  ADS  CAS  Google Scholar 

  4. Ellis, T., Wang, X. & Collins, J. J. Nature Biotechnol. 27, 465-471 (2009).

    Article  CAS  Google Scholar 

  5. Ro, D.-K. et al. Nature 440, 940-943 (2006).

    Article  ADS  CAS  Google Scholar 

  6. Tan, C., Marguet, P. & You, L. Nature Chem. Biol. 5, 842-848 (2009).

    Article  CAS  Google Scholar 

  7. An, W. & Chin, J. W. Proc. Natl Acad. Sci. USA 106, 8477-8482 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Elowitz, M. B. & Leibler, S. Nature 403, 335-338 (2000).

    Article  ADS  CAS  Google Scholar 

  9. Stricker, J. et al. Nature 456, 516-519 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Danino, T., Mondragón-Palomino, O., Tsimring, L. & Hasty, J. Nature 463, 326-330 (2010).

    Article  ADS  CAS  Google Scholar 

Download references


Additional information

See Editorial, page 269 .

Roberta Kwok is a freelance writer in the San Francisco Bay Area.

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Registry of Standard Biological Parts

International Genetically Engineered Machine competition

Ginkgo BioWorks

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Kwok, R. Five hard truths for synthetic biology. Nature 463, 288–290 (2010).

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