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Cell biology

A brake on lipid synthesis

Although sphingolipids are vital cellular components, the path to their production is paved with toxic intermediates. Orm proteins allow cells to form these lipids without killing themselves in the process.

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Figure 1: Orm proteins control sphingolipid homeostasis in the endoplasmic reticulum.

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Tafesse, F., Holthuis, J. A brake on lipid synthesis. Nature 463, 1028–1029 (2010). https://doi.org/10.1038/4631028a

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