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Diet and longevity in the balance

Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.

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Figure 1: Signalling pathways possibly influenced by dietary amino acids in Drosophila.


  1. Kirkwood, T. B. L. Nature 270, 301–304 (1977).

    Article  ADS  CAS  Google Scholar 

  2. Flatt, T. & Schmidt, P. Biochim. Biophys. Acta 1790, 951–962 (2009).

    Article  CAS  Google Scholar 

  3. Grandison, R. C., Piper, M. D. W. & Partridge, L. Nature 462, 1061–1064 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Mair, W. & Dillin, A. Annu. Rev. Biochem. 77, 727–754 (2008).

    Article  CAS  Google Scholar 

  5. Skorupa, D. A., Dervisefendic, A., Zwiener, J. & Pletcher, S. D. Aging Cell 7, 478–490 (2008).

    Article  CAS  Google Scholar 

  6. Min, K.-J. & Tatar, M. Mech. Ageing Dev. 127, 643–646 (2006).

    Article  CAS  Google Scholar 

  7. Troen, A. M. et al. Age 29, 29–39 (2007).

    Article  CAS  Google Scholar 

  8. Miller, R. A. et al. Aging Cell 4, 119–125 (2005).

    Article  CAS  Google Scholar 

  9. Zid, B. M. et al. Cell 139, 149–160 (2009).

    Article  CAS  Google Scholar 

  10. Géminard, C., Rulifson, E. J. & Léopold, P. Cell Metab. 10, 199–207 (2009).

    Article  Google Scholar 

  11. Tatar, M. & Carey, J. R. Ecology 76, 2066–2073 (1995).

    Article  Google Scholar 

  12. Crawford, D., Libina, N. & Kenyon, C. Aging Cell 6, 715–721 (2007).

    Article  CAS  Google Scholar 

  13. Wang, M. C., O'Rourke, E. J. & Ruvkun, G. Science 322, 957–960 (2008).

    Article  ADS  CAS  Google Scholar 

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Flatt, T. Diet and longevity in the balance. Nature 462, 989–990 (2009).

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