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DNA Replication

Prime-time looping

When the replication machinery copies DNA, it must unwind the double helix in one direction while synthesis of one of the strands proceeds in the other. Making transient DNA loops may solve this directional dilemma.

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Figure 1: DNA replication by a minimal replisome.
Figure 2: Three priming mechanisms.


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Dixon, N. Prime-time looping. Nature 462, 854–855 (2009).

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