Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunology

A helpers' guide to infection

Nature volume 462, pages 418–419 (2009)Cite this article

Killer T cells were thought to patrol the body unhindered, freely gaining access to sites of infection. But it seems that, at least in some body tissues, helper T cells must pave the way for killer T-cell entry.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Model of assisted entry.

Notes

  1. *This article and the paper under discussion3 were published online on 8 November 2009.

References

  1. Marshall, D. R. et al. Proc. Natl Acad. Sci. USA 98, 6313–6318 (2001).

    Article  ADS  CAS  Google Scholar 

  2. Masopust, D. et al. J. Immunol. 172, 4875–4882 (2004).

    Article  CAS  Google Scholar 

  3. Nakanishi, Y., Lu, B., Gerard, C. & Iwasaki, A. Nature 462, 510–513 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Jennings, S. R., Bonneau, R. H., Smith, P. M., Wolcott, R. M. & Chervenak, R. Cell. Immunol. 133, 234–252 (1991).

    Article  CAS  Google Scholar 

  5. Lund, J. M., Hsing, L., Pham, T. T. & Rudensky, A. Y. Science 320, 1220–1224 (2008).

    Article  ADS  CAS  Google Scholar 

  6. Zhao, X. et al. J. Exp. Med. 197, 153–162 (2003).

    Article  CAS  Google Scholar 

  7. Wakim, L. M., Waithman, J., van Rooijen, N., Heath, W. R. & Carbone, F. R. Science 319, 198–202 (2008).

    Article  ADS  CAS  Google Scholar 

  8. McLachlan, J. B., Catron, D. M., Moon, J. J. & Jenkins, M. K. Immunity 30, 277–288 (2009).

    Article  CAS  Google Scholar 

  9. Cunningham, A. L. et al. J. Clin. Invest. 75, 226–233 (1985).

    Article  CAS  Google Scholar 

  10. Marzo, A. L. et al. J. Immunol. 165, 6047–6055 (2000).

    Article  CAS  Google Scholar 

  11. Butcher, E. C. & Picker, L. J. Science 272, 60–66 (1996)

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thomas Gebhardt and Francis R. Carbone are in the Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.,

    Thomas Gebhardt & Francis R. Carbone

Authors
  1. Thomas Gebhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francis R. Carbone
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gebhardt, T., Carbone, F. A helpers' guide to infection. Nature 462, 418–419 (2009). https://doi.org/10.1038/462418a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/462418a

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing