Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Access denied?

Information-sharing resources are essential to biologists and deserve international support.

Every weekday, thousands of researchers around the world access the Arabidopsis Information Resource (TAIR), which contains the most reliable and up-to-date genomic information available on the most widely used model organism in the plant kingdom. But now, to those users' horror, TAIR faces collapse: the US National Science Foundation (NSF) is phasing out funding after 10 years as the data resource's sole supporter (see page 258).

TAIR's plight is emblematic of a broader crisis facing many of the world's biological databases and repositories. Research funding agencies recognize that such infrastructures are crucial to the ongoing conduct of science, yet few are willing to finance them indefinitely. Such agencies tend to support these resources during the development phase, but then expect them to find sustainable funding elsewhere.

The sharing of bioresources does not and should not stop at national borders.

Unfortunately, that is not easy. Other funding agencies are no more likely to provide long-term support than the agency that launched the resource in the first place. Moreover, any government agency's long-term plans are vulnerable to short-term political expediency. Witness, for example, Japan, where the new government has slashed the budget of the RIKEN BioResource Centre by one-third (see page 258).

Private firms are equally poor bets. Advertising and sponsorship are unlikely to bring in enough money to pay the experts needed to maintain such resources. And the superficially plausible idea of charging subscription fees is effectively unworkable for facilities such as TAIR, because the producers and consumers of data are essentially the same community. Scientists provide data and resources for free, because sharing benefits everyone. However, they would be considerably less likely to deposit the fruits of their labour if this synergy was removed from the equation. Subscription-based databases and resources would then enter a downward spiral, becoming less and less complete and so less and less valuable.

The problem is acute even for modest resources. Two examples are the kidney database EuReGene and the mouse-embryo database EURExpress, both of which were launched with funds from the European Commission that have run out in recent months. The databases are currently being maintained on a hand-to-mouth basis, and the scientists who built them don't know where to turn for maintenance money. Yet the European Commission's investment will have been wasted if the databases disappear.

It is time for a whole new approach. Front-line biology cannot function without these resources, so solutions must be found at both national and international levels.

Governments must ensure that at least one of their national funding agencies has money specifically set aside for the long-term support of bioresource infrastructures. A good model to emulate would be the United Kingdom's Biotechnology and Biological Sciences Research Council, which allows databases and other such resources to apply for ring-fenced funding, saving them from having to compete with hypothesis-driven grants, which are the agencies' mainstay.

But action is also needed on the international front. The sharing of bioresources does not and should not stop at national borders. For example, only about a quarter of TAIR users are based in the United States. China is the second biggest user at around 12%, followed by Japan at around 10%. This is not atypical. Yet it is difficult for a single national agency to justify maintaining a resource for the rest of the world. What is required is an international cost-sharing organization that could fund competitively selected infrastructures, large and small.

The European Commission has made a good start with projects such as ELIXIR (European Life Sciences Infrastructure for Biological Information), which is studying ways of steering national agencies towards the joint funding of bioresources. A global, ELIXIR-like initiative is urgently needed, run perhaps by an international, relatively unbureaucratic organization such as the Human Frontier Science Program.

But an international solution may be a long time coming. In the meantime, bioresource infrastructures might be wise to invest some time in public relations, giving paymasters a greater understanding of the consequences of their decisions.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Access denied?. Nature 462, 252 (2009).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing