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Chemical biology

A Notch above other inhibitors

A tenet of drug discovery states that molecules greater than a certain size don't enter cells. But not only do certain synthetic peptides refute this idea, they also inhibit 'undruggable' biological targets.

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Figure 1: Inhibition of the Notch signalling pathway.

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Arora, P., Ansari, A. A Notch above other inhibitors. Nature 462, 171–173 (2009). https://doi.org/10.1038/462171a

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