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Cancer

A tumour gene's fatal flaws

Mutations in RAS genes are common in human tumours, but RAS has proved impossible to target with drugs. Its associated NF-κB signalling pathway, however, may turn out to be this tumour gene's Achilles heel.

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Figure 1: The RAS and NF-κB signalling pathways.

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Downward, J. A tumour gene's fatal flaws. Nature 462, 44–45 (2009). https://doi.org/10.1038/462044a

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