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Immunology

In the beginning

Immune cells cross the inflamed blood–brain barrier. But it's unclear how brain inflammation begins before immune-cell entry. Studies of a model of multiple sclerosis start to solve this 'chicken and egg' conundrum.

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Figure 1: The first wave of immune-cell entry.
Figure 2: The second wave.

References

  1. Glabinski, A. R., Tani, M., Tuohy, V. K., Tuthill, R. J. & Ransohoff, R. M. Brain Behav. Immun. 9, 315–330 (1995).

    CAS  Article  Google Scholar 

  2. Gerard, C. & Rollins, B. J. Nature Immunol. 2, 108–115 (2001). | Article

    CAS  Article  Google Scholar 

  3. Piccio, L. et al. J. Immunol. 168, 1940–1949 (2002).

    CAS  Article  Google Scholar 

  4. Reboldi, A. et al. Nature Immunol. 10, 514–523 (2009).

    CAS  Article  Google Scholar 

  5. Bartholomäus, I. et al. Nature 462, 94–98 (2009).

    ADS  Article  Google Scholar 

  6. Galea, I., Bechmann, I. & Perry, V. H. Trends Immunol. 28, 12–18 (2007).

    CAS  Article  Google Scholar 

  7. Ransohoff, R. M. Nature 457, 155–156 (2009).

    ADS  CAS  Article  Google Scholar 

  8. Kivisakk, P. et al. Ann. Neurol. 65, 457–469 (2009).

    CAS  Article  Google Scholar 

  9. Kivisakk, P. et al. Proc. Natl Acad. Sci. USA 100, 8389–8394 (2003).

    ADS  Article  Google Scholar 

  10. Ransohoff, R. M., Kivisakk, P. & Kidd, G. Nature Rev. Immunol. 3, 569–581 (2003).

    CAS  Article  Google Scholar 

  11. Kawakami, N. et al. J. Exp. Med. 199, 185–197 (2004).

    CAS  Article  Google Scholar 

  12. Brown, D. A. & Sawchenko, P. E. J. Comp. Neurol. 502, 236–260 (2007).

    Article  Google Scholar 

  13. Axtell, R. C. & Steinman, L. Nature Immunol. 10, 453–455 (2009).

    CAS  Article  Google Scholar 

  14. Xu, H. et al. J. Neuroimmunol. 142, 47–57 (2003).

    CAS  Article  Google Scholar 

  15. Schenkel, A. R., Mamdouh, Z. & Muller, W. A. Nature Immunol. 5, 393–400 (2004). | Article

    CAS  Article  Google Scholar 

Download references

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Ransohoff, R. In the beginning. Nature 462, 41–42 (2009). https://doi.org/10.1038/462041a

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