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In the beginning

Immune cells cross the inflamed blood–brain barrier. But it's unclear how brain inflammation begins before immune-cell entry. Studies of a model of multiple sclerosis start to solve this 'chicken and egg' conundrum.

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Figure 1: The first wave of immune-cell entry.
Figure 2: The second wave.


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Ransohoff, R. In the beginning. Nature 462, 41–42 (2009).

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