Neuroscience

Alzheimer's disease

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The neurodegenerative disorder Alzheimer's disease is becoming more prevalent in ageing populations worldwide. The identification of effective treatments will require a better understanding of the physiological mechanisms involved, and innovative approaches to drug development and evaluation.

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Figure 1: Some key players in the pathogenesis of AD.
Figure 2: The challenge of finding AD biomarkers.

FURTHER READING

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    Alzheimer's Association 2009 Alzheimer's Disease Facts and Figures (2009).

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    Chin, J., Roberson, E. D. & Mucke, L. in Learning and Memory: A Comprehensive Reference Vol. 4 (ed. Byrne, J. H.) Ch. 15 (Academic, 2008).

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    Mahley, R. W., Weisgraber, K. H. & Huang, Y. Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl Acad. Sci. USA 103, 5644–5651 (2006).

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    Roberson, E. D. & Mucke, L. 100 years and counting: Prospects for defeating Alzheimer's disease. Science 314, 781–784 (2006).

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    http://www.alzforum.org

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    http://www.clinicaltrials.gov

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Competing interests

The author consults for Merck, has received research funding from Elan, and serves on the scientific advisory board of iPierian.

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See online at http://go.nature.com/phyLwm for more on neuroscience.

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Mucke, L. Alzheimer's disease. Nature 461, 895–897 (2009) doi:10.1038/461895a

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