An agenda for personalized medicine

Pauline C. Ng, Sarah S. Murray, Samuel Levy and J. Craig Venter find differences in results from two direct-toconsumer genetics-testing companies. They therefore give nine recommendations to improve predictions.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Frazer, K. A., Murray, S. S., Schork, N. J. & Topol, E. J. Nature Rev. Genet. 10, 241–251 (2009).

  2. 2

    Mailman, M. D. et al. Nature Genet. 39, 1181–1186 (2007).

  3. 3

    Heshka, J. T., Palleschi, C., Howley, H., Wilson, B. & Wells, P. S. Genet. Med. 10, 19–32 (2008).

  4. 4

    Hogarth, S., Javitt, G. & Melzer, D. Annu. Rev. Genomics Hum. Genet. 9, 161–182 (2008).

  5. 5

    Duncan, D. E. Experimental Man: What One Man's Body Reveals About His Future, Your Health, and Our Toxic World (John Wiley & Sons, 2009).

  6. 6

    Singer, E. Technology Review (MIT, 15 June, 2009); available at http://www.technologyreview.com/blog/editors/23680

  7. 7

    Topol, E. J., Murray, S. S. & Frazer, K. A. J. Am. Med. Assoc. 298, 218–221 (2007).

  8. 8

    Bertram, L., McQueen, M. B., Mullin, K., Blacker, D. & Tanzi, R.E. Nature Genet. 39, 17–23 (2007).

  9. 9

    Hsu, A. & Naughton, B. (eds) Guidelines on Vetting Genetic Associations (23andMe; 2008); available at https://23andme.https.internapcdn.net/res/4400/pdf/23-03_Vetting_Genetic_Associations.pdf

  10. 10

    Applying Preventive Genomic Medicine in Clinical Practice (Navigenics, 2008); available at http://www.navigenics.com/static/pdf/physician/physician-whitepaper.pdf

  11. 11

    Green, P. H. R. & Jabri, B. Lancet 362, 383–391 (2003).

  12. 12

    Hunt, K. A. et al. Nature Genet. 40, 395–402 (2008).

  13. 13

    Liu, Y. et al. PLoS Genet. 4, e1000041 (2008).

  14. 14

    Lazarou, J., Pomeranz, B. H. & Corey, P. N. J. Am. Med. Assoc. 279, 1200–1205 (1998).

  15. 15

    Pirmohamed, M. et al. Br. Med. J. 329, 15–19 (2004).

  16. 16

    Sangkuhl, K., Berlin, D. S., Altman, R. B. & Klein, T. E. Drug Metab. Rev. 40, 539–551 (2008).

  17. 17

    http://www.23andme.com/health/all

  18. 18

    http://www.pathway.com/more_info/drug_responses

  19. 19

    Personalized Medicine Coalition Personal Genomics and Industry Standards: Scientific Validity (2008); available at http://cancercontrol.cancer.gov/od/phg/docs/PMCSciValid.pdf

  20. 20

    Prainsack, B. et al. Nature 456, 34–35 (2008).

  21. 21

    Aulchenko, Y. S. et al. Nature Genet. 41, 47–55 (2009).

  22. 22

    Lyssenko, V. et al. N. Engl. J. Med. 359, 2220–2232 (2008).

  23. 23

    Meigs, J. B. et al. N. Engl. J. Med. 359, 2208–2219 (2008).

  24. 24

    Adeyemo, A. & Rotimi, C. Public Health Genomics doi: 10.1159/000218711 (2009).

  25. 25

    Easton, D. F. et al. Am. J. Hum. Genet. 81, 873–883 (2007).

Download references

Author information

Ethics declarations

Competing interests

Competing interests: PCN and SSM currently hold stock in Illumina, Inc.

Additional information

Supplementary information on the experimental methods.

See Editorial page 697 , and online at http://go.nature.com/VqPUE2 .

Supplementary information

Supplementary Information

Experimental methods and results. (PDF 93 kb)

Supplementary figures

Supplementary figures. (PDF 478 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ng, P., Murray, S., Levy, S. et al. An agenda for personalized medicine. Nature 461, 724–726 (2009). https://doi.org/10.1038/461724a

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.