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Developmental biology

A bad boy comes good

Reactive oxygen species are often blamed for the development of cancer and other diseases. Contrary to their 'bad boy' reputation, these species seem to be essential for the development of immune cells, at least in the fly.

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Figure 1: The good side of reactive oxygen species.


  1. Owusu-Ansah, E. & Banerjee, U. Nature 461, 537–541 (2009).

    ADS  CAS  Article  Google Scholar 

  2. Crozatier, M. & Meister, M. Cell. Microbiol. 9, 1117–1126 (2007).

    CAS  Article  Google Scholar 

  3. Martinez-Agosto, J. A., Mikkola, H. K., Hartenstein, V. & Banerjee, U. Genes Dev. 21, 3044–3060 (2007).

    CAS  Article  Google Scholar 

  4. Márkus, R. et al. Proc. Natl Acad. Sci. USA 106, 4805–4809 (2009).

    ADS  Article  Google Scholar 

  5. Essers, M. A. et al. EMBO J. 23, 4802–4812 (2004).

    CAS  Article  Google Scholar 

  6. Tothova, Z. et al. Cell 128, 325–339 (2007).

    CAS  Article  Google Scholar 

  7. Cumano, A. & Godin, I. Annu. Rev. Immunol. 25, 745–785 (2007).

    CAS  Article  Google Scholar 

  8. Doonan, R. et al. Genes Dev. 22, 3236–3241 (2008).

    CAS  Article  Google Scholar 

  9. Van Raamsdonk, J. M. & Hekimi, S. PLoS Genet. 5, e1000361 (2009).

    Article  Google Scholar 

  10. Bjelakovic, G. et al. J. Am. Med. Assoc. 297, 842–857 (2007).

    CAS  Article  Google Scholar 

  11. Niethammer, P., Grabher, C., Look, A. T. & Mitchison, T. J. Nature 459, 996–999 (2009).

    ADS  CAS  Article  Google Scholar 

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Theopold, U. A bad boy comes good. Nature 461, 486–487 (2009).

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