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Developmental biology

Rise of the source–sink model

Gradients of signalling molecules dictate where specific cell types form in developing tissues, but how these gradients are set up is much debated. A model proposed 40 years ago by Francis Crick may provide an answer.

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Figure 1: Models of morphogen dispersal.


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Schier, A., Needleman, D. Rise of the source–sink model. Nature 461, 480–481 (2009).

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