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Epigenetics

Ready for the marks

Genomic imprinting, in which genes are expressed from either the maternal or paternal genome, involves the addition of methyl marks to DNA. Paradoxically, demethylation of histone proteins is an essential first step.

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Figure 1: Imprinting involves histone demethylation and DNA methylation.

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Feil, R. Ready for the marks. Nature 461, 359–360 (2009). https://doi.org/10.1038/461359a

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