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Developmental biology

Instructions writ in blood

It seems that growth factors may instruct blood-cell progenitors to develop into specific mature cell types, actively determining lineage choice. But is this reductionist view of cell fate overly simplistic?

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Figure 1: Instructive and selective models of lineage choice.

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Enver, T., Jacobsen, S. Instructions writ in blood. Nature 461, 183–184 (2009). https://doi.org/10.1038/461183a

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