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Structural biology

DNA binding shapes up

DNA-binding proteins have the daunting task of finding their binding sites among the 3 billion base pairs of the human genome. The shape of DNA, and not just its sequence, may offer proteins much-needed direction.

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Figure 1: Getting into the groove.

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Tullius, T. DNA binding shapes up. Nature 461, 1225–1226 (2009). https://doi.org/10.1038/4611225a

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