Fluorescence microscopy is the most popular way to image biomolecules, but it leaves many of them in the dark. Non-fluorescent, light-absorbing molecules can now be viewed by a method that turns them into mini-lasers.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Min, W. et al. Nature 461, 1105–1109 (2009).
Schäfer, F. P. Dye Lasers (Springer, 1973).
Schawlow, A. L. & Townes, C. H. Phys. Rev. 112, 1940–1949 (1958).
Hell, S. W. & Wichmann, J. Opt. Lett. 19, 780–782 (1994).
Fu, D. et al. J. Biomed. Opt. 12, 054004 (2007).
Freudiger, C. W. et al. Science 322, 1857–1861 (2008).
Dong, C. Y., So, P. T. C., Buehler, C. & Gratton, E. Optik 106, 7–14 (1997).
Hell, S. W. Nature Biotechnol. 21, 1347–1355 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hell, S., Rittweger, E. Light from the dark. Nature 461, 1069–1070 (2009). https://doi.org/10.1038/4611069a
Published:
Issue Date:
DOI: https://doi.org/10.1038/4611069a