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Enzyme's black box cracked open

Polyketide synthase enzymes make compounds from molecules that synthetic chemists can't easily control. The basis of the enzymes' ability to use such unstable precursors has been laid bare.

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Figure 1: controlling the reactivity of polyketide chains.


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Sherman, D. Enzyme's black box cracked open. Nature 461, 1068–1069 (2009).

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