Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Molecular biology

Slip sliding on DNA

Dedicated binding proteins stabilize single-stranded DNA, protecting it from breakage and distortion. Once thought to form inert complexes with DNA, such proteins are now shown to be remarkably mobile.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Binding and removal of SSBs from DNA.


  1. Lohman, T. M. & Ferrari, M. E. Annu. Rev. Biochem. 63, 527–570 (1994).

    Article  CAS  Google Scholar 

  2. Shereda, R. D., Kozlov, A. G., Lohman, T. M., Cox, M. M. & Keck, J. L. Crit. Rev. Biochem. Mol. Biol. 43, 289–318 (2008).

    Article  CAS  Google Scholar 

  3. Roy, R., Kozlov, A. G., Lohman, T. M. & Ha, T. Nature 461, 1092–1097 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Wold, M. S. Annu. Rev. Biochem. 66, 61–92 (1997).

    Article  CAS  Google Scholar 

  5. Kornberg, A. & Baker, T. A. DNA Replication 2nd edn (Freeman, 1992).

    Google Scholar 

  6. Chrysogelos, S. & Griffith, J. Proc. Natl Acad. Sci. USA 79, 5803–5807 (1982).

    Article  ADS  CAS  Google Scholar 

  7. Clapier, C. R. & Cairns, B. R. Annu. Rev. Biochem. 78, 273–304 (2009).

    Article  CAS  Google Scholar 

  8. Römer, R. et al. Biochemistry 23, 6132–6137 (1984).

    Article  Google Scholar 

  9. Kuznetsov, S. V. et al. J. Mol. Biol. 359, 55–65 (2006).

    Article  CAS  Google Scholar 

  10. Lohman, T. M. & Kowalczykowski, S. C. J. Mol. Biol. 152, 67–109 (1981).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

George, N., Keck, J. Slip sliding on DNA. Nature 461, 1067–1068 (2009).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing