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Structural biology

A channel with a twist

Mechanosensitive channels release tension in cell membranes by opening 'pressure relief' pores. The structure of a partially open channel suggests a gating mechanism and delivers an unexpected architectural twist.

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Figure 1: Opening of the MscL channel.

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Vásquez, V., Perozo, E. A channel with a twist. Nature 461, 47–48 (2009). https://doi.org/10.1038/461047a

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