Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neuroscience

Activity acts locally

How does neuronal activity affect the development of neural circuits? Work on the retina shows that blocking activity at the synapses between neurons reduces local synapse assembly without affecting global cellular structure.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Blocking synaptic activity in the retina has local effects.

References

  1. 1

    Cline, H. & Haas, K. J. Physiol. (Lond.) 586, 1509–1517 (2008).

    CAS  Article  Google Scholar 

  2. 2

    Tian, N. J. Physiol. (Lond.) 586, 4347–4355 (2008).

    CAS  Article  Google Scholar 

  3. 3

    Kerschensteiner, D. et al. Nature 460, 1016–1020 (2009).

    CAS  ADS  Article  Google Scholar 

  4. 4

    Wässle, H. Nature Rev. Neurosci. 5, 747–757 (2004).

    Article  Google Scholar 

  5. 5

    Schiavo, G. et al. Nature 359, 832–835 (1992).

    CAS  ADS  Article  Google Scholar 

  6. 6

    Bodnarenko, S. R. & Chalupa, L. M. Nature 364, 144–146 (1993).

    CAS  ADS  Article  Google Scholar 

  7. 7

    Blankenship, A. G. et al. Neuron 62, 230–241 (2009).

    CAS  Article  Google Scholar 

  8. 8

    Nevin, L. M., Taylor, M. R. & Baier, H. Neural Dev. 3, 36 (2008).

    Article  Google Scholar 

  9. 9

    Sanes, J. R. & Yamagata, M. Annu. Rev. Cell Dev. Biol. doi:10.1146/annurev.cellbio.24.110707.175402 (2009).

  10. 10

    Sanes, J. R. & Lichtman, J. W. Annu. Rev. Neurosci. 22, 389–442 (1999).

    CAS  Article  Google Scholar 

  11. 11

    Bosman, L. W. & Konnerth, A. Neuroscience 162, 612–623 (2009).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Demb, J., Feller, M. Activity acts locally. Nature 460, 961–963 (2009). https://doi.org/10.1038/460961a

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing