Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


More than kin and less than kind

A gene that is found to be mutated in a type of blood cancer exhibits properties of both a growth-suppressing tumour suppressor and a growth-promoting oncogene.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Van Etten, R. A. & Shannon, K. M. Cancer Cell 6, 547–552 (2004).

    CAS  Article  Google Scholar 

  2. Sanada, M. et al. Nature 460, 904–908 (2009).

    CAS  ADS  Article  Google Scholar 

  3. Stephens, K. et al. Blood 108, 1684–1689 (2006).

    CAS  Article  Google Scholar 

  4. Fitzgibbon, J. et al. Cancer Res. 65, 9152–9154 (2005).

    CAS  Article  Google Scholar 

  5. Kralovics, R., Guan, Y. & Prchal, J. T. Exp. Hematol. 30, 229–236 (2002).

    CAS  Article  Google Scholar 

  6. Dunbar, A. J. et al. Cancer Res. 68, 10349–10357 (2008).

    CAS  Article  Google Scholar 

  7. Grand, F. H. et al. Blood 113, 6182–6192 (2009).

    CAS  Article  Google Scholar 

  8. Loh, M. L. et al. Blood doi:10.1182/blood-2009-01-198416 (2009).

  9. Schmidt, M. H. & Dikic, I. Nature Rev. Mol. Cell Biol. 6, 907–918 (2005).

    CAS  Article  Google Scholar 

  10. Rathinam, C. et al. Genes Dev. 22, 992–997 (2008).

    CAS  Article  Google Scholar 

  11. Kotecha, N. et al. Cancer Cell 14, 335–343 (2008).

    CAS  Article  Google Scholar 

  12. Mor, A. & Philips, M. R. Annu. Rev. Immunol. 24, 771–800 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Shannon, K., Loh, M. More than kin and less than kind. Nature 460, 805–807 (2009).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing