Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

More than kin and less than kind

A gene that is found to be mutated in a type of blood cancer exhibits properties of both a growth-suppressing tumour suppressor and a growth-promoting oncogene.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Van Etten, R. A. & Shannon, K. M. Cancer Cell 6, 547–552 (2004).

    Article  CAS  Google Scholar 

  2. Sanada, M. et al. Nature 460, 904–908 (2009).

    Article  CAS  ADS  Google Scholar 

  3. Stephens, K. et al. Blood 108, 1684–1689 (2006).

    Article  CAS  Google Scholar 

  4. Fitzgibbon, J. et al. Cancer Res. 65, 9152–9154 (2005).

    Article  CAS  Google Scholar 

  5. Kralovics, R., Guan, Y. & Prchal, J. T. Exp. Hematol. 30, 229–236 (2002).

    Article  CAS  Google Scholar 

  6. Dunbar, A. J. et al. Cancer Res. 68, 10349–10357 (2008).

    Article  CAS  Google Scholar 

  7. Grand, F. H. et al. Blood 113, 6182–6192 (2009).

    Article  CAS  Google Scholar 

  8. Loh, M. L. et al. Blood doi:10.1182/blood-2009-01-198416 (2009).

  9. Schmidt, M. H. & Dikic, I. Nature Rev. Mol. Cell Biol. 6, 907–918 (2005).

    Article  CAS  Google Scholar 

  10. Rathinam, C. et al. Genes Dev. 22, 992–997 (2008).

    Article  CAS  Google Scholar 

  11. Kotecha, N. et al. Cancer Cell 14, 335–343 (2008).

    Article  CAS  Google Scholar 

  12. Mor, A. & Philips, M. R. Annu. Rev. Immunol. 24, 771–800 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shannon, K., Loh, M. More than kin and less than kind. Nature 460, 805–807 (2009). https://doi.org/10.1038/460804a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/460804a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing