Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cells

Escaping fates with open states

The ability of embryonic stem cells to give rise to any cell type relies on a remodelling protein that maintains open chromatin. But the chromatin landscape of these cells may be more complex than previously thought.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Chd1 and open chromatin.


  1. Jaenisch, R. & Young, R. Cell 132, 567–582 (2008).

    Article  CAS  Google Scholar 

  2. Trojer, P. & Reinberg, D. Mol. Cell 28, 1–13 (2007).

    Article  CAS  Google Scholar 

  3. Gaspar-Maia, A. et al. Nature 460, 863–868 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Meshorer, E. et al. Dev. Cell 10, 105–116 (2006).

    Article  CAS  Google Scholar 

  5. Efroni, S. et al. Cell Stem Cell 2, 437–447 (2008).

    Article  CAS  Google Scholar 

  6. Sims, R. J. III et al. Mol. Cell 28, 665–676 (2007).

    Article  CAS  Google Scholar 

  7. Sims, R. J. III et al. J. Biol. Chem. 280, 41789–41792 (2005).

    Article  CAS  Google Scholar 

  8. Flanagan, J. F. et al. Nature 438, 1181–1185 (2005).

    Article  ADS  CAS  Google Scholar 

  9. Pavri, R. et al. Cell 125, 703–717 (2006).

    Article  CAS  Google Scholar 

  10. Konev, A. Y. et al. Science 317, 1087–1090 (2007).

    Article  ADS  CAS  Google Scholar 

  11. Zegerman, P., Canas, B., Pappin, D. & Kouzarides, T. J. Biol. Chem. 277, 11621–11624 (2002).

    Article  CAS  Google Scholar 

  12. Nishioka, K. et al. Genes Dev. 16, 479–489 (2002).

    Article  CAS  Google Scholar 

  13. Ooi, S. K. et al. Nature 448, 714–717 (2007).

    Article  ADS  CAS  Google Scholar 

  14. Fazzio, T. G., Huff, J. T. & Panning, B. Cell 134, 162–174 (2008).

    Article  CAS  Google Scholar 

  15. Berstein, B. E. et al. Cell 125, 315–326 (2006).

    Article  Google Scholar 

  16. Mikkelsen, T. S. et al. Nature 454, 49–55 (2008).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sims III, R., Reinberg, D. Escaping fates with open states. Nature 460, 802–803 (2009).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing