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Cellular control in two clicks

If complex tissues are to be engineered, synthetic materials will be needed that provide cells with precisely located molecular cues. A method that attaches such cues to specific areas of a gel could be the answer.

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Figure 1: Clicking into place.


  1. DeForest, C. A., Polizzotti, B. D. & Anseth, K. S. Nature Mater. doi:10.1038/nmat2473 (2009). | Article |

  2. Baskin, J. M. et al. Proc. Natl Acad. Sci. USA 104, 16793–16797 (2007).

    Article  ADS  CAS  Google Scholar 

  3. Cushing, M. C. & Anseth, K. S. Science 316, 1133–1134 (2007).

    Article  CAS  Google Scholar 

  4. Khademhosseini, A., Vacanti, J. P. & Langer, R. Sci. Am. 300 (5), 64–71 (2009).

    Article  ADS  CAS  Google Scholar 

  5. Burdick, J. A. & Vunjak-Novakovic, G. Tissue Eng. A 15, 205–219 (2009).

    Article  CAS  Google Scholar 

  6. Luo, Y. & Shoichet, M. S. Nature Mater. 3, 249–253 (2004).

    Article  ADS  CAS  Google Scholar 

  7. Khetan, S., Katz, J. S. & Burdick, J. A. Soft Matter 5, 1601–1606 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Lutolf, M. P. & Hubbell, J. A. Nature Biotechnol. 23, 47–55 (2005).

    Article  CAS  Google Scholar 

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Burdick, J. Cellular control in two clicks. Nature 460, 469–470 (2009).

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