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Immunology

B cells break the rules

A study of lymphocytes that lack a DNA-repair enzyme challenges long-standing dogma about the spatial separation of processes that rearrange antibody genes, and provides clues about the origins of B-cell cancers.

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Figure 1: Immunoglobulin gene rearrangements.
Figure 2: Chromosome translocations in B cells.

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Diaz, M., Daly, J. B cells break the rules. Nature 460, 184–186 (2009). https://doi.org/10.1038/460184a

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