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Stem cells

The promises and perils of p53

Five studies show that disabling p53, an essential tumour-suppressor protein, improves the efficiency of stem-cell production. Are these results a 'heads up' that cancer cells and stem cells are disturbingly similar?

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Figure 1: Overlapping mechanisms control iPS-cell and cancer-cell production.

Notes

  1. *This article and the papers concerned1,2,3,4,5 were were previously published online.

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Krizhanovsky, V., Lowe, S. The promises and perils of p53. Nature 460, 1085–1086 (2009). https://doi.org/10.1038/4601085a

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