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Cell biology

The proteasome assembly line

The assembly of the proteasome — the cellular machine that eliminates unwanted proteins — is a carefully choreographed affair, involving a complex sequence of steps overseen by dedicated protein chaperones.

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Figure 1: A model of proteasome regulatory-particle assembly1,2.

References

  1. Roelofs, J. et al. Nature 459, 861–865 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Park, S. et al. Nature 459, 866–870 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Smith, D. M. et al. Mol. Cell 27, 731–744 (2007).

    Article  CAS  Google Scholar 

  4. Gillette, T. G., Kumar, B., Thompson, D., Slaughter, C. A. & DeMartino, G. N. J. Biol. Chem. 283, 31813–31822 (2008).

    Article  CAS  Google Scholar 

  5. Ramos, C. P. & Dohmen, R. J. Structure 16, 1296–1304 (2008).

    Article  CAS  Google Scholar 

  6. Rosenzweig, R., Osmulski, P. A., Gaczynska, M. & Glickman, M. H. Nature Struct. Mol. Biol. 15, 573–580 (2008).

    Article  CAS  Google Scholar 

  7. Babbitt, S. E. et al. Cell 121, 553–565 (2005).

    Article  CAS  Google Scholar 

  8. Kriegenburg, F. et al. Cell 135, 355–365 (2008).

    Article  CAS  Google Scholar 

  9. Downes, M. & Evans, R. M. Cancer Cell 13, 184–185 (2008).

    Article  CAS  Google Scholar 

  10. Olanow, C. W. & McNaught, K. S. Mov. Disord. 21, 1806–1823 (2006).

    Article  Google Scholar 

  11. Goldberg, A. L. Biochem. Soc. Trans. 35, 12–17 (2007).

    Article  CAS  Google Scholar 

  12. Le Tallec, B., Barrault, M. B., Guérois, R., Carré, T. & Peyroche, A. Mol. Cell 33, 389–399 (2009).

    Article  CAS  Google Scholar 

  13. Nakamura, Y. et al. Biochem. Biophys. Res. Commun. 359, 503–509 (2007).

    Article  CAS  Google Scholar 

  14. Funakoshi, M., Tomko, R. J., Kobayashi, H. & Hochstrasser, M. Cell 137, 887–899 (2009).

    Article  CAS  Google Scholar 

  15. Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H. & Tanaka, K. Cell 137, 900–913 (2009).

    Article  CAS  Google Scholar 

  16. Kaneko, T. et al. Cell 137, 914–925 (2009).

    Article  CAS  Google Scholar 

Download references

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Madura, K. The proteasome assembly line. Nature 459, 787–788 (2009). https://doi.org/10.1038/459787a

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