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Developmental biology

Transgenic primate offspring

Nature volume 459, pages 515–516 (2009)Cite this article

Genetically engineered monkeys carrying a foreign gene that is passed on to their offspring provide a potentially valuable bridge between mouse models of disease and treatment for human disorders.

Mouse models of disease have been used in research into disorders ranging from anaemia and asthma to autism and schizophrenia. But not every human disease can be modelled faithfully in rodents. Mice engineered to express the cystic fibrosis gene, for example, do not develop the lung problems that typify this disorder (a pig model of cystic fibrosis2 proved more useful). Disorders of higher brain function, such as Alzheimer's disease, are especially challenging to reproduce in rodents, and here, as with many other diseases, it is our closest animal relatives — the non-human primates — that offer potentially invaluable biological models.

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Author information

Authors and Affiliations

  1. Gerald Schatten is in the Departments of Obstetrics, Gynecology and Reproductive Sciences, and of Cell Biology, Physiology and Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. gschatten@pdc.magee.edu,

    Gerald Schatten

  2. Shoukhrat Mitalipov is in the Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA. mitalipo@ohsu.edu,

    Shoukhrat Mitalipov

Authors
  1. Gerald Schatten
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  2. Shoukhrat Mitalipov
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Schatten, G., Mitalipov, S. Transgenic primate offspring. Nature 459, 515–516 (2009). https://doi.org/10.1038/459515a

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