Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer

Melanoma troops massed

Nature volume 459, pages 336–337 (2009)Cite this article

In many cancers, regulation of specific signalling molecules goes awry, affecting a host of other proteins and cellular processes. Proteomics is a useful systemic approach for identifying such extensive effects.

In most Western countries, the incidence of melanoma — a form of skin cancer linked to exposure to sunlight — doubles roughly every decade. Early removal of melanoma lesions leads to a good prognosis, but the outlook for patients with advanced melanoma is often bleak owing to a lack of effective treatments. To develop better therapies, a deeper understanding of this cancer's biology is needed. To this end, a paper published by Old and colleagues1 in Molecular Cell, which reports on a new use of a proteomics technique to identify molecules regulating melanoma-cell behaviour, is a welcome advance.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

Figure 1: The BRAF-mediated pathway in health and cancer.

References

  1. Old, W. M. et al. Mol. Cell 34, 115–131 (2009).

    CAS  Article  Google Scholar 

  2. Gray-Schopfer, V., Wellbrock, C. & Marais, R. Nature 445, 851–857 (2007).

    ADS  CAS  Article  Google Scholar 

  3. Hanahan, D. & Weinberg, R. A. Cell 100, 57–70 (2000).

    CAS  Article  Google Scholar 

  4. Sarno, S. & Pinna, L. A. Mol. Biosyst. 4, 889–894 (2008).

    CAS  Article  Google Scholar 

  5. Ritt, D. A. et al. Curr. Biol. 17, 179–184 (2007).

    CAS  Article  Google Scholar 

  6. Garnett, M. J., Rana, S., Paterson, H., Barford, D. & Marais, R. Mol. Cell 20, 963–969 (2005).

    CAS  Article  Google Scholar 

  7. Dumaz, N. et al. Cancer Res. 66, 9483–9491 (2006).

    CAS  Article  Google Scholar 

  8. Specht, K. M. & Shokat, K. M. Curr. Opin. Cell Biol. 14, 155–159 (2002).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Paul H. Huang and Richard Marais are at the Institute of Cancer Research, London SW3 6JB, UK. richard.marais@icr.ac.uk ,

    Paul H. Huang & Richard Marais

Authors
  1. Paul H. Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard Marais
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Huang, P., Marais, R. Melanoma troops massed. Nature 459, 336–337 (2009). https://doi.org/10.1038/459336a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/459336a

Further reading

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing