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Melanoma troops massed

In many cancers, regulation of specific signalling molecules goes awry, affecting a host of other proteins and cellular processes. Proteomics is a useful systemic approach for identifying such extensive effects.

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Figure 1: The BRAF-mediated pathway in health and cancer.


  1. Old, W. M. et al. Mol. Cell 34, 115–131 (2009).

    CAS  Article  Google Scholar 

  2. Gray-Schopfer, V., Wellbrock, C. & Marais, R. Nature 445, 851–857 (2007).

    ADS  CAS  Article  Google Scholar 

  3. Hanahan, D. & Weinberg, R. A. Cell 100, 57–70 (2000).

    CAS  Article  Google Scholar 

  4. Sarno, S. & Pinna, L. A. Mol. Biosyst. 4, 889–894 (2008).

    CAS  Article  Google Scholar 

  5. Ritt, D. A. et al. Curr. Biol. 17, 179–184 (2007).

    CAS  Article  Google Scholar 

  6. Garnett, M. J., Rana, S., Paterson, H., Barford, D. & Marais, R. Mol. Cell 20, 963–969 (2005).

    CAS  Article  Google Scholar 

  7. Dumaz, N. et al. Cancer Res. 66, 9483–9491 (2006).

    CAS  Article  Google Scholar 

  8. Specht, K. M. & Shokat, K. M. Curr. Opin. Cell Biol. 14, 155–159 (2002).

    CAS  Article  Google Scholar 

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Huang, P., Marais, R. Melanoma troops massed. Nature 459, 336–337 (2009).

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