In many cancers, regulation of specific signalling molecules goes awry, affecting a host of other proteins and cellular processes. Proteomics is a useful systemic approach for identifying such extensive effects.
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References
Old, W. M. et al. Mol. Cell 34, 115–131 (2009).
Gray-Schopfer, V., Wellbrock, C. & Marais, R. Nature 445, 851–857 (2007).
Hanahan, D. & Weinberg, R. A. Cell 100, 57–70 (2000).
Sarno, S. & Pinna, L. A. Mol. Biosyst. 4, 889–894 (2008).
Ritt, D. A. et al. Curr. Biol. 17, 179–184 (2007).
Garnett, M. J., Rana, S., Paterson, H., Barford, D. & Marais, R. Mol. Cell 20, 963–969 (2005).
Dumaz, N. et al. Cancer Res. 66, 9483–9491 (2006).
Specht, K. M. & Shokat, K. M. Curr. Opin. Cell Biol. 14, 155–159 (2002).
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Huang, P., Marais, R. Melanoma troops massed. Nature 459, 336–337 (2009). https://doi.org/10.1038/459336a
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DOI: https://doi.org/10.1038/459336a
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