Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell biology

A score for membrane fusion

Intracellular membrane fusion has been mimicked in vitro using a mix of 17 purified proteins and lipid bilayers. This technical tour de force allows the study of how cells orchestrate and perform such fusion events.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Proteins work together to mediate endosomal membrane fusion.

References

  1. Schoenheimer, R. The Dynamic State of Body Constituents (Harvard Univ. Press, 1942).

    Google Scholar 

  2. Ohya, T. et al. Nature 459, 1091–1097 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Ungar, D. & Hughson, F. M. Annu. Rev. Cell Dev. Biol. 19, 493–517 (2003).

    Article  CAS  Google Scholar 

  4. Wickner, W. & Schekman, R. Nature Struct. Mol. Biol. 15, 658–664 (2008).

    Article  CAS  Google Scholar 

  5. Grosshans, B. L., Ortiz, D. & Novick, P. Proc. Natl Acad. Sci. USA 103, 11821–11827 (2006).

    Article  ADS  CAS  Google Scholar 

  6. Skehel, J. J. & Wiley, D. C. Cell 95, 871–874 (1998).

    Article  CAS  Google Scholar 

  7. Weber, T. et al. Cell 92, 759–772 (1998).

    Article  CAS  Google Scholar 

  8. Singer-Krüger, B. et al. J. Cell Biol. 125, 283–298 (1994).

    Article  Google Scholar 

  9. Shnyrova, A. V. et al. J. Cell Biol. 179, 627–633 (2007).

    Article  CAS  Google Scholar 

  10. Zwilling, D. et al. EMBO J. 26, 9–18 (2007).

    Article  CAS  Google Scholar 

  11. Martincic, I., Peralta, M. E. & Ngsee, J. K. J. Biol. Chem. 272, 26991–26998 (1997).

    Article  CAS  Google Scholar 

  12. Kuzmin, P. I. et al. Proc. Natl Acad. Sci. USA 98, 7235–7240 (2001).

    Article  ADS  CAS  Google Scholar 

  13. Bashkirov, P. V. et al. Cell 135, 1276–1286 (2008).

    Article  CAS  Google Scholar 

  14. Martens, S., Kozlov, M. M. & McMahon, H. T. Science 316, 1205–1208 (2007).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Collins, R., Zimmerberg, J. A score for membrane fusion. Nature 459, 1065–1066 (2009). https://doi.org/10.1038/4591065a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/4591065a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing