Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Structural biology

Protein dynamics from disorder

Nature volume 459, pages 1063–1064 (2009)Cite this article

The functions of proteins are often crucially dependent on how they move, but measuring the absolute magnitudes of protein motions hasn't been possible. A spectroscopic method looks set to change all that.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Molecular alignment enables the detection of protein dynamics.

References

  1. Salmon, L. et al. Angew. Chem. Int. Edn 48, 4154–4157 (2009).

    Article  CAS  Google Scholar 

  2. Perutz, M. F. & Mathews, F. S. J. Mol. Biol. 21, 199–202 (1966).

    Article  CAS  Google Scholar 

  3. Bustamante, C. Annu. Rev. Biochem. 77, 45–50 (2008).

    Article  CAS  Google Scholar 

  4. Mittermaier, A. & Kay, L. E. Science 312, 224–228 (2006).

    Article  ADS  CAS  Google Scholar 

  5. Meiler, J., Prompers, J. J., Peti, W., Griesinger, C. & Brüschweiler, R. J. Am. Chem. Soc. 123, 6098–6107 (2001).

    Article  CAS  Google Scholar 

  6. Tolman, J. R. J. Am. Chem. Soc. 124, 12020–12030 (2002).

    Article  CAS  Google Scholar 

  7. Tjandra, N., Feller, S. E., Pastor, R. W. & Bax, A. J. Am. Chem. Soc. 117, 12562–12566 (1995).

    Article  CAS  Google Scholar 

  8. Briggman, K. B. & Tolman, J. R. J. Am. Chem. Soc. 125, 10164–10165 (2003).

    Article  CAS  Google Scholar 

  9. Lange, O. F. et al. Science 320, 1471–1475 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Peti, W., Meiler, J., Brüschweiler, R. & Griesinger, C. J. Am. Chem. Soc. 124, 5822–5833 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Joel R. Tolman is in the Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA. tolman@jhu.edu,

    Joel R. Tolman

Authors
  1. Joel R. Tolman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tolman, J. Protein dynamics from disorder. Nature 459, 1063–1064 (2009). https://doi.org/10.1038/4591063a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/4591063a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing