Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Protein dynamics from disorder

The functions of proteins are often crucially dependent on how they move, but measuring the absolute magnitudes of protein motions hasn't been possible. A spectroscopic method looks set to change all that.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Molecular alignment enables the detection of protein dynamics.


  1. Salmon, L. et al. Angew. Chem. Int. Edn 48, 4154–4157 (2009).

    CAS  Article  Google Scholar 

  2. Perutz, M. F. & Mathews, F. S. J. Mol. Biol. 21, 199–202 (1966).

    CAS  Article  Google Scholar 

  3. Bustamante, C. Annu. Rev. Biochem. 77, 45–50 (2008).

    CAS  Article  Google Scholar 

  4. Mittermaier, A. & Kay, L. E. Science 312, 224–228 (2006).

    ADS  CAS  Article  Google Scholar 

  5. Meiler, J., Prompers, J. J., Peti, W., Griesinger, C. & Brüschweiler, R. J. Am. Chem. Soc. 123, 6098–6107 (2001).

    CAS  Article  Google Scholar 

  6. Tolman, J. R. J. Am. Chem. Soc. 124, 12020–12030 (2002).

    CAS  Article  Google Scholar 

  7. Tjandra, N., Feller, S. E., Pastor, R. W. & Bax, A. J. Am. Chem. Soc. 117, 12562–12566 (1995).

    CAS  Article  Google Scholar 

  8. Briggman, K. B. & Tolman, J. R. J. Am. Chem. Soc. 125, 10164–10165 (2003).

    CAS  Article  Google Scholar 

  9. Lange, O. F. et al. Science 320, 1471–1475 (2008).

    ADS  CAS  Article  Google Scholar 

  10. Peti, W., Meiler, J., Brüschweiler, R. & Griesinger, C. J. Am. Chem. Soc. 124, 5822–5833 (2002).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tolman, J. Protein dynamics from disorder. Nature 459, 1063–1064 (2009).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing