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Structural biology

Protein dynamics from disorder

The functions of proteins are often crucially dependent on how they move, but measuring the absolute magnitudes of protein motions hasn't been possible. A spectroscopic method looks set to change all that.

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Figure 1: Molecular alignment enables the detection of protein dynamics.

References

  1. Salmon, L. et al. Angew. Chem. Int. Edn 48, 4154–4157 (2009).

    CAS  Article  Google Scholar 

  2. Perutz, M. F. & Mathews, F. S. J. Mol. Biol. 21, 199–202 (1966).

    CAS  Article  Google Scholar 

  3. Bustamante, C. Annu. Rev. Biochem. 77, 45–50 (2008).

    CAS  Article  Google Scholar 

  4. Mittermaier, A. & Kay, L. E. Science 312, 224–228 (2006).

    ADS  CAS  Article  Google Scholar 

  5. Meiler, J., Prompers, J. J., Peti, W., Griesinger, C. & Brüschweiler, R. J. Am. Chem. Soc. 123, 6098–6107 (2001).

    CAS  Article  Google Scholar 

  6. Tolman, J. R. J. Am. Chem. Soc. 124, 12020–12030 (2002).

    CAS  Article  Google Scholar 

  7. Tjandra, N., Feller, S. E., Pastor, R. W. & Bax, A. J. Am. Chem. Soc. 117, 12562–12566 (1995).

    CAS  Article  Google Scholar 

  8. Briggman, K. B. & Tolman, J. R. J. Am. Chem. Soc. 125, 10164–10165 (2003).

    CAS  Article  Google Scholar 

  9. Lange, O. F. et al. Science 320, 1471–1475 (2008).

    ADS  CAS  Article  Google Scholar 

  10. Peti, W., Meiler, J., Brüschweiler, R. & Griesinger, C. J. Am. Chem. Soc. 124, 5822–5833 (2002).

    CAS  Article  Google Scholar 

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Tolman, J. Protein dynamics from disorder. Nature 459, 1063–1064 (2009). https://doi.org/10.1038/4591063a

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