Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Translation

Till termination us do part

Translation of messenger RNA into protein is a complex and intricate process involving several steps and many step-specific protein factors. But one factor — eIF5A — seems to have a hand in every step.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Saini, P., Eyler, D. E., Green, R. & Dever, T. E. Nature 459, 118–121 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Hershey, J. W. B. & Merrick, W. C. In Translational Control of Gene Expression (eds Sonenberg, N., Hershey, J. W. B. & Mathews, M. B.) 33–88 (Cold Spring Harbor Press, 2000).

    Google Scholar 

  3. Kemper, W. M., Berry, K. W. & Merrick, W. C. J. Biol. Chem. 251, 5551–5557 (1976).

    CAS  PubMed  Google Scholar 

  4. Cooper, H. L. et al. Proc. Natl Acad. Sci. USA 80, 1854–1857 (1983).

    Article  ADS  CAS  Google Scholar 

  5. Gordon, E. D. et al. J. Biol. Chem. 262, 16585–16589 (1987).

    CAS  PubMed  Google Scholar 

  6. Park, M. H. et al. J. Biol. Chem. 266, 7988–7994 (1991).

    CAS  PubMed  Google Scholar 

  7. Kyrpides, N. C. & Woese, C. R. Proc. Natl Acad. Sci. USA 95, 224–228 (1998).

    Article  ADS  CAS  Google Scholar 

  8. Labib, K., Tercero, J. A. & Diffley, J. F. Science 288, 1643–1647 (2000).

    Article  ADS  CAS  Google Scholar 

  9. Woese, C. Nature 226, 817–820 (1970).

    Article  ADS  CAS  Google Scholar 

  10. Moran, S. J., Flanagan, J. F. 4th, Namy, O., Stuart, D. I., Brierlye, I. & Gilbert, R. J. Structure 16, 664–672 (2008).

    Article  CAS  Google Scholar 

  11. Passmore, L. A. et al. Mol. Cell 26, 41–50 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Merrick, W. Till termination us do part. Nature 459, 44–45 (2009). https://doi.org/10.1038/459044a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/459044a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing