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Neuroscience

A bar code for differentiation

Regulating neuronal development can be complicated. But genetic control of neurotransmitter expression — as exemplified by differentiation of dopamine-secreting neurons — turns out to be relatively straightforward.

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Figure 1: Orchestrating neurotransmitter expression.

References

  1. Flames, N. & Hobert, O. Nature 458, 885–889 (2009).

    ADS  CAS  Article  Google Scholar 

  2. Duggan, A., Ma, C. & Chalfie, M. Development 125, 4107–4119 (1998).

    CAS  PubMed  Google Scholar 

  3. Etchberger, J. F. et al. Genes Dev. 21, 1653–1674 (2007).

    CAS  Article  Google Scholar 

  4. Wenick, A. S. & Hobert, O. Dev. Cell 6, 757–770 (2004).

    CAS  Article  Google Scholar 

  5. Hsiau, T. H.-C. et al. PLoS ONE 2, e643 (2007).

    ADS  Article  Google Scholar 

  6. Shirasaki, R. & Pfaff, S. L. Annu. Rev. Neurosci. 25, 251–281 (2002).

    CAS  Article  Google Scholar 

  7. Weintraub, H. et al. Proc. Natl Acad. Sci. USA 86, 5434–5438 (1989).

    ADS  CAS  Article  Google Scholar 

  8. Halder, G., Callaerts, P. & Gehring, W. J. Science 267, 1788–1792 (1995).

    ADS  CAS  Article  Google Scholar 

  9. Hobert, O. Proc. Natl Acad. Sci. USA 105, 20067–20071 (2008).

    ADS  CAS  Article  Google Scholar 

Download references

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Spitzer, N. A bar code for differentiation. Nature 458, 843–844 (2009). https://doi.org/10.1038/458843a

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