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Drug discovery

Fresh target for cancer therapy

The Byzantine system for degrading proteins inside cells is already the target of a successful anticancer drug. A compound that inhibits another part of this system also shows promise in models of cancer in mice.

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Figure 1: Activation of CRL enzymes by the NEDD8 protein.
Figure 2: Structure of an NAE inhibitor.


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Deshaies, R. Fresh target for cancer therapy. Nature 458, 709–710 (2009).

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