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Cutting off cancer's supply lines

Targeting the blood vessels that feed tumours is not the silver bullet once hoped for, but refinements to the strategy may suggest further ways to treat the disease. Erika Check Hayden reports.

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  1. Folkman, J. N. Engl. J. Med. 285, 1182–1186 (1971).

    Article  CAS  Google Scholar 

  2. Pàez-Ribes, M. et al. Cancer Cell 15, 220–231 (2009).

    Article  Google Scholar 

  3. Ebos, J. M. L. et al. Cancer Cell 15, 232–239 (2009).

    Article  CAS  Google Scholar 

  4. Reynolds, A. R. et al. Nature Med. doi:10.1038/nm.1941 (2009).

  5. Pennacchietti, S. et al. Cancer Cell 3, 347–361 (2003).

    Article  Google Scholar 

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US National Cancer Institute fact sheet on angiogenesis inhibitors

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Hayden, E. Cutting off cancer's supply lines. Nature 458, 686–687 (2009).

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