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Secret of synapse specificity

How does the brain organize all of the information stored in memory? On the basis of a state-of-the-art imaging study of neuronal activity in real time, the answer seems to be, through specificity in space and time.

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Figure 1: Synapse-specific long-term potentiation (LTP).


  1. Malenka, R. C. & Bear, M. F. Neuron 44, 5–21 (2004).

    Article  CAS  Google Scholar 

  2. Matynia, A., Kushner, S. A. & Silva, A. J. Annu. Rev. Genet. 36, 687–720 (2002).

    Article  CAS  Google Scholar 

  3. Andersen, P., Sundberg, S. H., Sveen, O. & Wigström, H. Nature 266, 736–737 (1977).

    Article  ADS  CAS  Google Scholar 

  4. Lynch, G. S., Dunwiddie, T. & Gribkoff, V. Nature 266, 737–739 (1977).

    Article  ADS  CAS  Google Scholar 

  5. Harvey, C. D., Yasuda, R., Zhong, H. & Svoboda, K. Science 321, 136–140 (2008).

    Article  ADS  CAS  Google Scholar 

  6. Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M. & Yasuda, R. Nature 458, 299–304 (2009).

    Article  ADS  CAS  Google Scholar 

  7. Lisman, J., Schulman, H. & Cline, H. Nature Rev. Neurosci. 3, 175–190 (2002).

    Article  CAS  Google Scholar 

  8. Yasuda, R. Curr. Opin. Neurobiol. 16, 551–561 (2006).

    Article  CAS  Google Scholar 

  9. Takao, K. et al. J. Neurosci. 25, 3107–3112 (2005).

    Article  CAS  Google Scholar 

  10. Ganesan, S. et al. Proc. Natl Acad. Sci. USA 103, 4089–4094 (2006).

    Article  ADS  CAS  Google Scholar 

  11. Rose, J., Jin, S. X. & Craig, A. M. Neuron 61, 351–358 (2009).

    Article  CAS  Google Scholar 

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Thompson, S., Mattison, H. Secret of synapse specificity. Nature 458, 296–297 (2009).

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