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The nuances of therapy

Oncologists use drugs that limit a tumour's blood supply to prevent its growth. Although the initial effects of these drugs are beneficial to patients, new data suggest that their long-term effects warrant further study.

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Figure 1: The MRI evidence.



  1. Pàez-Ribes, M. et al. Cancer Cell 15, 220–231 (2009).

    Article  Google Scholar 

  2. Ebos, J. M. L. et al. Cancer Cell 15, 232–239 (2009).

    Article  CAS  Google Scholar 

  3. Ellis, L. M. & Hicklin, D. J. Nature Rev. Cancer 8, 579–591 (2008).

    Article  CAS  Google Scholar 

  4. Ferrara, N. et al. Nature 380, 439–442 (1996).

    Article  ADS  CAS  Google Scholar 

  5. Lee, S. et al. Cell 130, 691–703 (2007).

    Article  CAS  Google Scholar 

  6. Ebos, J. M. L. et al. Proc. Natl Acad. Sci. USA 104, 17069–17074 (2007).

    Article  ADS  CAS  Google Scholar 

  7. Du, R. et al. Cancer Cell 13, 206–220 (2008).

    Article  CAS  Google Scholar 

  8. Grothey, A. et al. J. Clin. Oncol. 26, 5326–5334 (2008).

    Article  CAS  Google Scholar 

  9. Escudier, B. et al. N. Engl. J. Med. 356, 125–134 (2007).

    Article  CAS  Google Scholar 

  10. Llovet, J. M. et al. N. Engl. J. Med. 359, 378–390 (2008).

    Article  CAS  Google Scholar 

  11. Vredenburgh, J. J. et al. J. Clin. Oncol. 25, 4722–4729 (2007).

    Article  CAS  Google Scholar 

  12. Kopetz, S. et al. Proc. 2009 Gastrointest. Cancers Symp. Abstr. 292 (Am. Soc. Clin. Oncol., 2009).

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Ellis, L., Reardon, D. The nuances of therapy. Nature 458, 291–292 (2009).

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