Oncologists use drugs that limit a tumour's blood supply to prevent its growth. Although the initial effects of these drugs are beneficial to patients, new data suggest that their long-term effects warrant further study.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Consensus guidelines for the use and interpretation of angiogenesis assays
Angiogenesis Open Access 15 May 2018
-
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
Angiogenesis Open Access 31 January 2014
-
Contrasting effects of sunitinib within in vivo models of metastasis
Angiogenesis Open Access 28 July 2012
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pàez-Ribes, M. et al. Cancer Cell 15, 220–231 (2009).
Ebos, J. M. L. et al. Cancer Cell 15, 232–239 (2009).
Ellis, L. M. & Hicklin, D. J. Nature Rev. Cancer 8, 579–591 (2008).
Ferrara, N. et al. Nature 380, 439–442 (1996).
Lee, S. et al. Cell 130, 691–703 (2007).
Ebos, J. M. L. et al. Proc. Natl Acad. Sci. USA 104, 17069–17074 (2007).
Du, R. et al. Cancer Cell 13, 206–220 (2008).
Grothey, A. et al. J. Clin. Oncol. 26, 5326–5334 (2008).
Escudier, B. et al. N. Engl. J. Med. 356, 125–134 (2007).
Llovet, J. M. et al. N. Engl. J. Med. 359, 378–390 (2008).
Vredenburgh, J. J. et al. J. Clin. Oncol. 25, 4722–4729 (2007).
Kopetz, S. et al. Proc. 2009 Gastrointest. Cancers Symp. Abstr. 292 (Am. Soc. Clin. Oncol., 2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ellis, L., Reardon, D. The nuances of therapy. Nature 458, 291–292 (2009). https://doi.org/10.1038/458290a
Published:
Issue Date:
DOI: https://doi.org/10.1038/458290a
This article is cited by
-
Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies
Drug Delivery and Translational Research (2021)
-
Humanized mouse models of immunological diseases and precision medicine
Mammalian Genome (2019)
-
Consensus guidelines for the use and interpretation of angiogenesis assays
Angiogenesis (2018)
-
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
Angiogenesis (2014)
-
Innovations in studying in vivo cell behavior and pharmacology in complex tissues – microvascular endothelial cells in the spotlight
Cell and Tissue Research (2013)