Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neuroscience

Good and bad cell death

Neurodegeneration often has disease connotations. However, it is also a developmental process for fine sculpting of the nervous system. One signalling cascade might mediate the process in both circumstances.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Neurodegeneration signalling cascade.

References

  1. Thinakaran, G. & Koo, E. H. J. Biol. Chem. 283, 29615–29619 (2008).

    Article  CAS  Google Scholar 

  2. Mattson, M. P. Nature 430, 631–639 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Walsh, D. M. & Selkoe, D. J. J. Neurochem. 101, 1172–1184 (2007).

    Article  CAS  Google Scholar 

  4. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M. & Tessier-Lavigne, M. Nature 457, 981–989 (2009).

    Article  ADS  CAS  Google Scholar 

  5. Pan, G. et al. FEBS Lett. 431, 351–356 (1998).

    Article  CAS  Google Scholar 

  6. Ashkenazi, A. & Dixit, V. M. Curr. Opin. Cell Biol. 11, 255–260 (1999).

    Article  CAS  Google Scholar 

  7. Kumar, S. Cell Death Differ. 14, 32–43 (2007).

    Article  CAS  Google Scholar 

  8. Gervais, F. G. et al. Cell 97, 395–406 (1999).

    Article  CAS  Google Scholar 

  9. Graham, R. K. et al. Cell 125, 1179–1191 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nicholson, D. Good and bad cell death. Nature 457, 970–971 (2009). https://doi.org/10.1038/457970a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/457970a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing