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Developmental biology

Birth of the blood cell

Could it be that mouse fetal liver cells and adult bone-marrow blood cells originate from a subset of cells that line the blood vessels in the embryo? Several lines of evidence suggest that this is indeed the case.

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Figure 1: Relationship between endothelial cells and blood cells.


  1. Lancrin, C. et al. Nature 457, 892–895 (2009).

    ADS  CAS  Article  Google Scholar 

  2. Eilken, H. M., Nishikawa, S.-I. & Schroeder, T. Nature 457, 896–900 (2009).

    ADS  CAS  Article  Google Scholar 

  3. Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E. & Speck, N. A. Nature 457, 887–891 (2009).

    ADS  CAS  Article  Google Scholar 

  4. Choi, K., Kennedy, M., Kazarov, A., Papadimitriou, J. C. & Keller, G. Development 125, 725–732 (1998).

    CAS  Article  Google Scholar 

  5. Huber, T. L., Kouskoff, V., Fehling, H. J., Palis, J. & Keller, G. Nature 432, 625–630 (2004).

    ADS  CAS  Article  Google Scholar 

  6. Nishikawa, S. I. et al. Immunity 8, 761–769 (1998).

    CAS  Article  Google Scholar 

  7. de Bruijn, M. F. et al. Immunity 16, 673–683 (2002).

    CAS  Article  Google Scholar 

  8. Yokomizo, T. et al. Genes Cells 6, 13–23 (2001).

    CAS  Article  Google Scholar 

  9. Zovein, A. C. et al. Cell Stem Cell 3, 625–636 (2008).

    CAS  Article  Google Scholar 

  10. Dzierzak, E. & Speck, N. A. Nature Immunol. 9, 129–136 (2008).

    CAS  Article  Google Scholar 

  11. Gurdon, J. B. & Melton, D. A. Science 322, 1811–1815 (2008).

    ADS  CAS  Article  Google Scholar 

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Yoshimoto, M., Yoder, M. Birth of the blood cell. Nature 457, 801–803 (2009).

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