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Evolutionary genetics

Origins of reproductive isolation

A rare example of gene incompatibility between two species of budding yeast has been found. This discovery of elusive 'speciation' genes adds to other reproductive-isolation mechanisms operating in yeasts.

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Figure 1: Hybrid sterility due to incompatibility between nuclear and mitochondrial genomes.


  1. Coyne, J. A. Nature 355, 511–515 (1992).

    Article  ADS  CAS  Google Scholar 

  2. Coyne, J. A. & Orr, H. A. Speciation (Sinauer, 2004).

    Google Scholar 

  3. Dobzhansky, T. Genetics and the Origin of Species (Columbia Univ. Press, 1937).

    Google Scholar 

  4. Greig, D. Heredity 102, 39–44 (2009).

    Article  CAS  Google Scholar 

  5. Lee, H.-Y. et al. Cell 135, 1065–1073 (2008).

    Article  CAS  Google Scholar 

  6. Naumov, G. I. Stud. Mycol. 30, 469–475 (1987).

    Google Scholar 

  7. Heck, J. A. et al. Proc. Natl Acad. Sci. USA 103, 3256–3261 (2006).

    Article  ADS  CAS  Google Scholar 

  8. Seidel, H. S., Rockman, M. V. & Kruglyak, L. Science 319, 589–594 (2008).

    Article  CAS  Google Scholar 

  9. Dettman, J. R., Sirjusingh, C., Kohn, L. M. & Anderson, J. B. Nature 447, 585–588 (2007).

    Article  ADS  CAS  Google Scholar 

  10. Hittinger, C. T., Rokas, A. & Carroll, S. B. Proc. Natl Acad. Sci. USA 101, 14144–14149 (2004).

    Article  ADS  CAS  Google Scholar 

  11. Dunn, B. & Sherlock, G. Genome Res. 18, 1610–1623 (2008).

    Article  CAS  Google Scholar 

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Louis, E. Origins of reproductive isolation. Nature 457, 549–550 (2009).

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