Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Evolutionary genetics

Origins of reproductive isolation

A rare example of gene incompatibility between two species of budding yeast has been found. This discovery of elusive 'speciation' genes adds to other reproductive-isolation mechanisms operating in yeasts.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Hybrid sterility due to incompatibility between nuclear and mitochondrial genomes.


  1. 1

    Coyne, J. A. Nature 355, 511–515 (1992).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Coyne, J. A. & Orr, H. A. Speciation (Sinauer, 2004).

    Google Scholar 

  3. 3

    Dobzhansky, T. Genetics and the Origin of Species (Columbia Univ. Press, 1937).

    Google Scholar 

  4. 4

    Greig, D. Heredity 102, 39–44 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Lee, H.-Y. et al. Cell 135, 1065–1073 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Naumov, G. I. Stud. Mycol. 30, 469–475 (1987).

    Google Scholar 

  7. 7

    Heck, J. A. et al. Proc. Natl Acad. Sci. USA 103, 3256–3261 (2006).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Seidel, H. S., Rockman, M. V. & Kruglyak, L. Science 319, 589–594 (2008).

    CAS  Article  Google Scholar 

  9. 9

    Dettman, J. R., Sirjusingh, C., Kohn, L. M. & Anderson, J. B. Nature 447, 585–588 (2007).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Hittinger, C. T., Rokas, A. & Carroll, S. B. Proc. Natl Acad. Sci. USA 101, 14144–14149 (2004).

    ADS  CAS  Article  Google Scholar 

  11. 11

    Dunn, B. & Sherlock, G. Genome Res. 18, 1610–1623 (2008).

    CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Louis, E. Origins of reproductive isolation. Nature 457, 549–550 (2009).

Download citation

Further reading


Quick links